mcq

mandatory answer

Question 1

a

Question 2

As a result of abnormal chromosome disjunction during meiosis an ovum
with 22 autosomes and polar body with 24 chromosomes were formed. What
syndrome the child can have in case of fertilization of such ovum by normal
spermatozoon (22+X)?

Question 3

While studying family pedigree with hypertrichosis (hyperhirsutism of ear)
the sign was founded only in men and it was inherited from father to the son.
Define the type of hypertrichosis inheritance?

Question 4

A family of students who came from Africa got a child with anemia signs.
The child died soon. Examination revealed that the child s erythrocytes had
abnormal semilunar shape. Specify genotypes of the child s parents:

Question 5

As a result of prophylactic medical examination a 7 year old boy was
diagnosed with Lesch-Nyhan syndrome (only boys fall ill with it). The boy s
parents are healthy but his grandfather by his mother s side suffers from the same
disease. What type of inheritance is it?

Question 6

Autopsy of a newborn boy revealed polydactylia, microcephalia,
cheiloschisis and uranoschisis as well as hypertrophy of parenchimatous organs.
These defects correspond with description of Patau''s syndrome. What is the most
probable cause of this pathology?

Question 7

At heterozygous parents with ?? (A) and ??? (B) blood groups on AB0
system the child was born. What is the probability of this child to have ? (0) blood
group?

Question 8

Formation of interferon in human cells, which is developed for protection
against viruses, is connected with interaction of genes. What of the listed types of
gene interactions does cause the interferon synthesis?

Question 9

Children of one family are analyzed. One parent is homozygous in
dominant gene of polydactyly, another is healthy (homozygous in recessive gene).
What law will be manifested at children in this case?

Question 10

Part of DNA chain turned about 180 degree due to gamma radiation. What
type of mutation took place in DNA chain?

Question 11

In human the same genotype can cause progress of disease with different
degrees of display of phenotypes. The degree of display of a trait in realization of a
genotype in different environmental conditions is named:

Question 12

It is known that the gene responsible for development of blood groups
according to AB0 system has three allele variants. If a man has IV blood group, it
can be explained by the following variability form:

Question 13

At what blood groups on Rhesus factor system at parents the rhesus
disease is possible during pregnancy?

Question 14

A woman with ??? (B), Rh- blood group born a child with ?? (A) blood
group. The child is diagnosed with hemolytic disease of newborn as a result of
rhesus incompatibility. What blood group is the childs father likely to have?

Question 15

A woman applied to the medico-genetic consulting centre for information
about the risk of haemophilia in her son. Her husband has been suffering from this
disease since birth. Woman and her parents are healthy (don''t have haemophilia).
Is the boy likely to have the disease in this family?

Question 16

At deaf-mute parents with DDee and ddEE genotypes children with
normal hearing were born. What is the form of D and E gene interaction?

Question 17

A man suffering from a hereditary disease married a healthy woman. They
got 5 children, three girls and two boys. All the girls inherited their father’s
disease. What is the type of the disease inheritance?

Question 18

At a man the ?V (??) and at a woman the ??? (B) blood groups are
established on AB0 system. The woman''s father has ? (0) blood group. In their
family 5 children were born. Specify a genotype of the child that can be considered
as a sideslip:

Question 19

White-haired, with blue eyes girl was born to healthy parents. Irritability,
anxiety, troubled sleep and feeding developed in the first months of life of the
infant. What method of genetic investigation should be used for the exact
diagnosis?

Question 20

One of variants of dental enamel coloring in human is defined by
interaction of two allelic genes in type of incomplete dominance. These genes form
and define:

Question 21

46 chromosomes were revealed during karyotype examination of the 5-
year-old girl. One of the 15th pair of chromosomes is longer than usual due to
connected chromosome from the 21 pair. What type of mutation does this girl
have?

Question 22

A man is homozygous in dominant gene of dark coloring of teeth enamel,
and his wife''s teeth have normal coloring. What law will be manifested at their
children?

Question 23

Medical examination at the military registration and enlistment office
revealed that a 15-year-old boy was high, with eunuchoid body proportions,
gynecomastia, female pattern of pubic hair distribution. The boy had also fat
deposits on the thighs, no facial hair, high voice, subnormal intelligence quotient.
Which karyotype corresponds with this disease?

Question 24

Examination of cell culture got from a patient with lysosomal pathology
revealed accumulation of great quantity of lipids in the lysosomes. What of the
following diseases is this disturbance typical for?

Question 25

A cell at the stage of mitosis anaphase was stimulated by colchicine that
inhibits chromosome separation to the poles. What type of mutation will be
caused?

Question 26

It is known, that a gene responsible for development of blood groups in
MN system has two allelic conditions. If M gene is considered as initial,
occurrence of allelic N gene took place owing to:

Question 27

A woman with ? (O) Rh- blood group has married a man with ?V (AB)

Rh+ blood group. What blood group and Rhesus factor is expected at their
children?

Question 28

A boy has I (I 0 I 0 ) blood group and his sister has IV (I A I B ) blood group.
What blood groups do their parents have?

Question 29

Hartnup disease is caused by point mutation of only one gene which
results in disturbance of tryptophane absorption in the bowels and its resorption in
the renal tubules. It is the reason for disorder of both digestive and urination
systems. What genetic phenomenon is observed in this case?

Question 30

Cytogenetic examination of a patient with reproductive dysfunction
revealed normal karyotype 46 ?Y in some cells, but most cells have karyotype of
Klinefelter''s syndrome – 47 ??Y. Such cell heterogenity is called:

Question 31

A 28-year-old female patient consulted a gynecologist about sterility.
Examination revealed underdeveloped ovaries and uterus, irregular menstrual
cycle. Analysis of the sex chromatin revealed 2 Barr’s bodies in most somatic
cells. What chromosomal disease is most likely?

Question 32

Define the distance between genes C and K if at crossing of
diheterozygous organism with the homozygous recessive individual 12% of
recombinants were received:

Question 33

Disease, caused by dominant gene localized in X-chromosome, is exposed
at sick man. Who from the children will have this disease if the wife is healthy?

Question 34

Albino (albinism is inherited as autosomal-recessive trait) with normal
blood coagulation and ? (0) blood group addressed to the genetic consultation.
What of the listed genotypes is most possible at this woman?

Question 35

Replacement of one of adenylic nucleotides with cytidylic is revealed in
the genetic apparatus of the human cells. What type of mutation is it?

Question 36

What is the probability of a birth of a sick child at phenotypically healthy
parents if mother is heterozygous carrier of a gene of the disease at X-linked
recessive type of inheritance?

Question 37

An albino child was born at the Black. What type of gene interactions can explain absence of skin pigmentation at this child?

Question 38

Signs of anemia are manifested at clinically healthy people in high
mountain regions. Sickle cells are revealed at blood tests. Sickle-cell anemia is
inherited as overdominance. Specify a genotype of such people:

Question 39

Biochemists have established that hemoglobin of the adult person contains
2-alpha and 2-beta polypeptide chains. The genes coding these chains are located
in different pairs of homologous chromosomes. What form of gene interaction
does occur between genes?

Question 40

Initial order of genes in a chromosome was ???defg. Under influence of
the mutagen factor there was a restructuring of this site to ???fg. What is the name
of such change?

Question 41

Let''s assume, that one pair of alleles controls progress of crystalline lens,
and the another pair controls progress of retina. In this case normal vision will be
result of gene interaction: